Vagus nerve stimulation for intractable epilepsy in children

Presurgical thalamocortical connectivity is associated with response to vagus nerve stimulation in children with intractable epilepsy

Although chronic vagus nerve stimulation (VNS) is an established treatment for medically-intractable childhood epilepsy, there is considerable heterogeneity in seizure response and little data are available to pre-operatively identify patients who may benefit from treatment. Since the therapeutic effect of VNS may be mediated by afferent projections to the thalamus, we tested the hypothesis tha...

Reassessment: vagus nerve stimulation for epilepsy.

A July 1997 assessment of the American Academy of Neurology (AAN) Therapeutics and Technology Subcommittee reviewed vagus nerve stimulation (VNS) for epilepsy, and concluded that it was promising, but not yet established. Subsequent to that review, a second multicenter, randomized, controlled clinical trial has shown safety and efficacy of VNS for treatment of intractable partial seizures. Give...

Vagus nerve stimulation for epilepsy: a review

Vagus nerve stimulation is an empirically based method for treatment of epilepsy by repeated stimulation of the left vagus nerve through implanted electrodes. Despite studies in animals and man, which show changes in brain electrophysiology, metabolism and neurochemistry, the mode of action remains unknown. Clinical testing has presented methodological challenges, as it is difficult to assess u...

Vagus Nerve Stimulation Therapy for Epilepsy

Assessment of Vagus Nerve Stimulation for Epilepsy

Introduction and methodology. Despite a recent surge in availability of new antiepileptic medications and advances in surgical therapy for epilepsy, intractable epilepsy remains a very significant problem. At least 25 to 50% of patients with epilepsy suffer from breakthrough seizures or debilitating side effects of medications. We need a safe and effective treatment for these people, even if it...